Every neighborhood is different. So check if any offenders live nearby. Megan’s law requires law enforcement authorities to make information regarding sex offenders public knowledge. A Google of your city follow by Megan’s law will yield you the results.
Secondly, check if the home was previously a junkie’s laboratory. There is a database by the Justice Department that list all addresses where law enforcement has found secret drug laboratories or dump sites. I am pretty sure I do not need to remind you of the health risk of living in such houses where the chemicals are still present. Click this link here: Justice Department Clandestine Lab database
Third, you want to check the crime rate of the neighborhood you are going to be checking out. A a bit of research will give you a peace of mind. Check out SpotCrime for a comprehensive source of crime info.